Ogies. However, the complex multifaceted functions of IL-1, sometimes beneficial and at other times deleterious, make IL-1 a difficult clinical target. INTERLEUKIN-33 IL-33 is a member of the IL-1 family that is mainly expressed in the epithelium lining the surfaces in contact with the environment. IL-33 has long been considered to exclusively mediate type-2 immune responses. However, recent findi